Heui-Il Kang,Yun-Beom Ham,Su-Hyun Kyong,Heung-Mo Kang,Tae-Hee Han,Doo-Jin Kang
申请号：
US13881204
公开号：
US09018349B2
申请日:
2011.01.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a novel process for preparing the aza cyclohexapeptide compound 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0 (caspofungin) represented by the following formula 1, which can improve the problem due to a pungent odor and toxicity during the process and can prepare caspofungin as a final product at high yield compared to conventional processes, and to novel intermediates which are used in the preparation process:
