#$%^&*AU2017203225A120171214.pdf#####ABSTRACT A MONOCLONAL ANTIBODY INHIBITING IMMUNOSUPPRESSIVE FUNCTIONS OF PATHOGENS, ANTIGEN-BINDING FRAGMENT THEREOF, AND HYBRIDOMAS PRODUCING SUCH ANTIBODY The present invention relates to a monoclonal antibody that inhibits immunosuppressive functions of pathogens, antigen-binding fragment thereof, and hybridomas producing such antibody. The monoclonal antibody or antigen-binding fragment thereof bind to a peptide consisting an amino acid sequence represented by MEKVGKDGVITVE (SEQ ID NO: 1). The present invention also discloses use of the invented monoclonal antibody or antigen-binding fragment thereof, and method of preparation for such hybridomas.1 -OmHpHSP60 --- rGFP --- Boiled HpHSP60 120 110 100 90 80 70* , 60 0 0.02 0.2 2 20 200 ng Fig. 1 5.D T cell 04 Non-T cell 4 3 .2 2 0 1 11 1 1 Anti-CD3 + + + + HpHSP60 - + - + Fig. 2
