This application involves anti-PD-L1 antibody or its antigen-binding fragments, encode its nucleic acid, its therapeutic composition, and they raise cell-mediated immune response with the function of what enhancing T cell and treat T cell dysfunctional illness with what, such as tumour immunity, and the purposes with what treating cancer.本申請涉及抗PD-L1抗體或其抗原結合片段,編碼其的核酸,其治療性組合物,以及它們用於增強T細胞的功能以上調細胞介導的免疫應答和用於治療T細胞功能失調性病症,例如腫瘤免疫,和用於治療癌症的用途。