BARDROFF, MICHAEL OTTO,BRANNETTI, BARBARA,CAMPBELL, EMMA MICHELLE,DIEFENBACH-STREIBER, BEATE,EBERTH, ADINA,KUNZ, CHRISTIAN CARSTEN SILVESTER,MARSHALL, SYLWIA,RONDEAU, JEAN-MICHEL RENE,SCHLAEPPI, JEAN-
申请号：
PE2015000304
公开号：
PE20150649A1
申请日:
2013.09.05
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The characteristic is that IL-18 involves both inherent immunity and obtaining immunity. The biological activity of IL-18 is negatively regulated by IL-18 binding protein (il18bp).A natural, very special inhibitor This soluble protein is formed by a free type i-18 compound, which prevents it from contacting with the type i-18 receptor, thus inhibiting and inhibiting its biological activities. The invention shows the linking molecules, including antibodies or fragments thereof, which are connected with IL-18, are not connected with IL-18, and are connected with IL-18BP (IL-18 / IL-18BP). In addition to physiological functionsThe i-18 has been shown to be an intermediate in a variety of autoimmune and flammable diseases. The chain molecule of the invention can be used as a therapeutic molecule for the treatment of autoimmunity and inflammation related to IL-18, or as a diagnostic tool for identifying, detecting and / or measuring IL-18 not connected with IL-18BP, as a component of the total reserve of IL-18.Caracterizado por: La IL-18 participa en la inmunidad tanto innata como adquirida. La bioactividad de IL-18 es negativamente regulada por la proteina de enlace a IL-18 (IL18BP), un inhibidor de origen natural y altamente especifico. Esta proteina soluble forma un complejo con la IL-18 libre que impide su interaccion con el receptor de IL-18, neutralizando e inhibiendo, por consiguiente, su actividad biologica. La invencion da a conocer moleculas de enlace, en particular anticuerpos o fragmentos de los mismos, que se enlazan a la IL-18 y no se enlazan a la IL-18 enlazada a IL-18BP (complejo de IL-18/IL-18BP). Aparte de su funcion fisiologica, se ha demostrado que la IL-18 media una variedad de enfermedades autoinmunes e inflamatorias. Las moleculas de enlace de la invencion se pueden utilizar como moleculas terapeuticas para el tratamiento de enfermedades autoinmunes e inflamatorias relacionadas con la IL-18, o como herramientas de diagnostico para caracterizar, det
