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PRODUCTION METHOD FOR GLYCOPROTEIN HAVING HUMAN-TYPE SUGAR CHAIN
专利权人:
PHYTON HOLDINGS LLC
发明人:
申请号:
JP20120171688
公开号:
JP2012223198(A)
申请日:
2012.08.02
申请国别(地区):
日本
年份:
2012
代理人:
摘要:
<p><P>PROBLEM TO BE SOLVED: To provide useful glycoprotein having a human-type sugar chain. <P>SOLUTION: There is provided a production method for glycoprotein having a human-type sugar chain, which includes: a step of obtaining a transformed plant cell by introducing the gene of glycosyltransferase and the gene of heterologous glycoprotein into a plant cell; and a step of culturing the obtained transformed plant cell. The glycosyltransferase can perform transfer reaction of a galactose residue to a unreduced terminal acetylglucosamine residue. The glycoprotein having the human-type sugar chain comprises a core sugar chain and an external sugar chain, the core chain comprises plural mannoses and acetylglucosamines, and the external sugar chain comprises a terminal sugar chain portion having a unreduced terminal galactose and has a linear chain structure or a branched structure. The glycoprotein having the human-type sugar chain comprises neither fucose nor xylose, so it does not exhibit antigenicity to humans. <P>COPYRIGHT: (C)2013,JPO&INPIT</p>
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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