PURPOSE: A wide ranged pathogenic virus pest management, a manufacturing method thereof and an extermination method using the same are provided to maintain extermination property even when the pest is directly spray on soil or excrements of domestic animals.CONSTITUTION: A wide ranged pathogenic virus pest management comprises 2 or more pH buffer, surfactant and non-bonding protein structure denaturant. In the pathogenic virus pest management, pH is controlled to be 2.6-5.5 by the pH buffer. The pH buffer is an organic acid having the pKa 2.2-6.0. The pH buffer is inorganic acid having pKa 2.2-6.0. The surfactant is cationic surfactant, anionic surfactant, non-ionic surfactant or ampholytic surfactant. The non-binding protein structure denaturant element is urea, guanidine hydrochloride or heavy metal salt. A prevention method of the pathogenic virus sprays the virus preventing agent. The pathogenic virus preventing agent has pH of 2.6-5.5 by dissolving 0.5-20 wt% of pH buffer, 0.3-6M of urea, and 0.1-2.0 wt% of alkylpolyglucoside in water.COPYRIGHT KIPO 2013[Reference numerals] (A1,A2) 0 minute (B1,B2) 1 minute (C1,C2) 3 minutes (D1,D2) 5 minutes (EE) Practical example 1 (FF) Comparative example 1본 발명은 pH 완충제, 계면활성제 및 필요에 따라 변성제를 포함하는 병원성 바이러스 방역제에 관한 것으로, 상기 구성에 의하면 용액의 pH를 마일드한 수준으로 유지할 수 있어 차량 내지 사람의 피부에 닿아도 차체 부식이나 피부 트러블을 일으키지 않고, 흙이나 가축의 분뇨에도 직접 살포하더라도 방제력을 잃지 않는 병원성 바이러스 방역제, 이의 제조방법 및 이를 이용한 방역방법을 제공한다.