Non-human animals exhibiting upper and lower motor neuron function and sensory decay

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专利权人:

リジェネロン・ファーマシューティカルズ・インコーポレイテッド

发明人:

イキズ， ブルチン,ラクロワ－フラリッシュ， マイケル,クロール， スーザン ディー．

申请号：

JP2017548965

公开号：

JP6600694B2

申请日:

2016.03.16

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

An animal model for motor neuron dysfunction in disease, e.g., amyotrophic lateral sclerosis (ALS), comprising a genetically modified non-human animal that comprises a genetically modified DR6 allele and exhibits normal phenotypes at birth and for a few weeks or months after birth. However, as the non-human animal ages, it develops motor neuron dysfunction that presents as one or more ALS-like symptoms, which may progress rapidly after onset. Methods of identifying candidate agents that may be used to prevent, delay or treat ALS are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/