NAGY, GÁBOR,HENICS, TAMÁS,SZIJÁRTO, VALERIA,NAGY, ESZTER
申请号：
SG11201501697U
公开号：
SG11201501697UA
申请日:
2013.09.05
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
A live attenuated Shigella vaccine, which is based on a rough Shigella strain lacking LPS O-antigen which is non-invasive through a mutation of the invasion plasmid, specifically for use in the immunoprophylaxis of a subject to prevent infectious diseases, preferably enteral disease, and a Shigella strain, which is a S. flexneri 2a strain with a deletion of the rfbF, ipaB and/or ipaC genes, as well as a recombinant plasmid vector based on a mutated Shigella invasion plasmid comprising a nucleotide sequence encoding at least one heterologous antigen, wherein the plasmid is mutated in at least one of the ipaB and/or ipaC genes.
