NAGY, GABOR,HENICS, TAMAS,SZIJARTO, VALERIA,NAGY, ESZTER
申请号：
IN2367DEN2015
公开号：
IN2367DEN2015A
申请日:
2015.03.23
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
A live attenuated Shigella vaccine, which is based on a rough Shigella strain lacking LPS O -antigen which is non- invasive through a mutation of the invasion plasmid , specifically for use in the immunoprophylaxis of a subject to prevent infectious diseases preferably enteral disease , and a Shigella strain, which is a S. flexneri 2a strain with a deletion of the rfb F, ipa B and/or ipa C genes , as well as a recombinant plasmid vector based on a mutated Shigella invasion plasmid comprising a nucleotide sequence encoding at least one heterologous antigen , wherein the plasmid is mutated in at least one of the ipa B and/or ipa C genes.
