HARIRI, ROBERT J.,KAPLUNOVSKY, ALEKSANDR M.,MURPHY, PATRICIA A.
申请号：
CA2479903
公开号：
CA2479903C
申请日:
2003.03.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to collagenous membranes produced from amnion,herein referred to as a collagen biofabric. The collagen biofabric of theinvention has the structural integrity of the native non-treated amnioticmembrane, i.e., the native tertiary and quaternary structure. The presentinvention provides a method for preparing a collagen biofabric from aplacental membrane, preferably a human placental membrane having a chorionicand amniotic membrane, by decellularizing the amniotic membrane. In apreferred embodiment, the amniotic membrane is completely decellularized. Thecollagen biofabric of the invention has numerous utilities in the medical andsurgical field including for example, blood vessel repair, construction andreplacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefitsof the biofabric are, in part, due to its physical properties such asbiomechanical strength, flexibility, suturability, and low immunogenicity,particularly when derived from human placenta.
