TRABANCO-SUÁREZ ANDRÉS AVELINO,MACDONALD GREGOR JAMES,GIJSEN HENRICUS JACOBUS MARIA,ROMBOUTS FREDERIK JAN RITA,BISCHOFF FRANÇOIS PAUL,ALONSO-DE DIEGO SERGIO-ALVAR,VELTER ADRIANA INGRID,VAN ROOSBROECK
申请号：
NZ70261113
公开号：
NZ702611A
申请日:
2013.05.16
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present invention is concerned with novel substituted 3,4-dihydro-2H-pyrido[1,2- a]pyrazine-1,6-dione derivatives of Formula (I) wherein R1, R2, R3, R4, R5, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
