The present invention discloses an embeddable patch for transdermal drug delivery and method of manufacturing the same. The embeddable patch for transdermal drug delivery comprises a supporting substrate, on which the surface includes a plurality of extruding supporting bases a biodegradable carrier, which is formed of biodegradable polymer material and disposed on the supporting base and drugs, which are encapsulated in the biodegradable carrier. When the embeddable patch for transdermal drug delivery is attached to the skin for a predetermined time, the biodegradable carrier is separated from the supporting bases and embedded into the skin, and the biodegradable carrier may swell and then degrade, so as to release the drugs, which are encapsulated in the biodegradable carrier, at a rate of 1% loaded drug per day~99% loaded drug per day into the skin. Accordingly, velocity of releasing the drugs may be regulated, so as to sustain the drug efficacy.本發明揭露一種鑲嵌式經皮藥物釋放貼片及其製造方法。該鑲嵌式經皮藥物釋放貼片包含支持基材,其表面包含複數個突狀支持軸;生物可分解性載體,其係由生物可分解性高分子材料所形成且設置於支持軸上;以及包覆於生物可分解性載體中之藥物。當鑲嵌式經皮藥物釋放貼片貼附於皮膚上一預定時間後,生物可分解性載體係與支持軸分離而鑲嵌於皮膚中,且生物可分解性載體可於皮膚中膨潤後再降解而將包覆於生物可分解性載體中之藥物以1%/天~99%/天之速率釋放於皮膚中。藉此,可調控藥物釋放之速率,以使藥效更加持久。1‧‧‧鑲嵌式經皮藥物釋放貼片10‧‧‧支持基材11‧‧‧載體12‧‧‧藥物102‧‧‧支持軸
