Shanghai Hengrui Pharmaceutical Co. Ltd.;Jiangsu Hengrui Medicine Co. Ltd.
发明人:
申请号：
EP14878154.5
公开号：
EP3093295A1
申请日:
2014.12.25
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention relates to an IL-15 heterodimeric protein and uses thereof and further relates to an IL-15/IL-15Rα heterodimeric protein. The IL-15 heterodimeric protein comprises protein (I) and protein (II), wherein said protein (I) is reassembled and formed by IL-15 or its variant with a first Fc variant； wherein said protein (II) is the second Fc variant, or reassembled and formed by IL-15Rα or its variant with a second Fc variant. The first Fc variant and the second Fc variant are linked via "Knob-into-Hole" mode. The IL-15 heterodimeric protein of the present invention has significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to IL-15 molecule alone.
