William J. Grossman,Mary A. Antonysamy,Richard M. Walsh,Mariana I. Nelson,Nandita Bose,Michael E. Danielson,Kyle S. Michel
申请号：
US16118909
公开号：
US20180369376A1
申请日:
2018.08.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure describes, in one aspect, a composition that includes a β-glucan component and an antibody component that specifically binds to the β-glucan. In another aspect, this disclosure describes a method of increasing a subject's response to β-glucan immunotherapy. Generally, the method includes identifying the subject as a low binder of β-glucan and administering to the subject a composition that comprises a β-glucan moiety conjugated to the therapeutic antibody. In some cases, the therapeutic antibody can be an anti-tumor antibody.
