ADMINISTRATION OF INGENOL MEBUTATE

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专利权人:

发明人:

Steven M. Ogbourne

申请号：

US14195842

公开号：

US20140249218A1

申请日:

2014.03.03

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention relates to novel crystalline forms of ingenol ingenol-3-angelate and methods of preparation and use thereof. More specifically, the invention relates to a novel crystalline form and purified forms of the compound of Formula 1 (ingenol-3-mebutate ingenol-3-angelate isoform ‘b’ PEP005), which is characterized by, for example, attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy, single crystal X-Ray crystallography (XRC), X-ray powder diffraction, and, Differential Scanning Calorimetry (DSC), and methods of preparation and use thereof.

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