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Melt extrusion of salts of active ingredients
专利权人:
Hans-Ulrich Petereit
发明人:
Hans-Ulrich Petereit,Christian Meier,Andreas Gryczke
申请号:
US10498829
公开号:
US08642089B2
申请日:
2003.01.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention relates to a method for producing active ingredient-containing granules or powders involving the following steps: a) melting a mixture consisting of a pharmaceutical active ingredient and of a (meth)acrylate copolymer, which is comprised of 40 to 75 wt. % of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and can be comprised of 25 to 60 wt. % (meth)acrylate monomers having an anionic group in the alkyl radial b) extruding the mixture, and c) comminuting the extrudate to form a granule or powder. The inventive method is characterized in that the active ingredient is the salt of an alkaline substance, and in that the pH value, which can be measured on the obtained powder or granule, is equal to or less than pH 7.0. The invention also relates to pharmaceutical dosage forms or precursors thereof, which can be produced using the inventive method.
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