It is an object of the invention to provide for a system that can be used to improve a cancer related clinical workflow compared to the current cancer related clinical workflow. This object is achieved by an image guided system configured for supporting a combined biopsy and treatment procedure using image guidance to bring a needle from a defined location to a predetermined end location in a subject of interest. The image guidance system comprises a medical imaging system (580) configured for acquisition of medical images of a region of interest (403) in the subject of interest, wherein the medical images are used to determine a current position of the predetermined end location (404). The image guidance system further comprises needle guidance system (402, 403) configured for defining a needle position in space and thereby defining the defined location (405, 406) and configured for guiding a biopsy and treatment needle into the region of interest. The image guidance system also comprises a user interface system (530) configured for supporting both the biopsy and treatment procedure, such that a patient setup needs to be executed only once. The user interface system (530) comprises a calibration unit (540) for aligning the needle guidance system (402, 403) with the medical images.
