University of Maryland, Baltimore;The United States of America as Represented by the Department of Veterans Affairs
发明人:
J. Marc Simard,Mingkui Chen
申请号：
US16752301
公开号：
US20200163902A1
申请日:
2020.01.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is directed to therapeutic compositions targeting the NCCa-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, agonists and antagonists of the NCCa-ATP channel are contemplated. The therapeutic compositions are used to treat cancer, more specifically, a metastatic brain tumor, wherein a tumor-brain barrier is present. Such treatments are contemplated in combination with conventional anti-cancer therapies. Alternatively, the compositions are used to prevent cell death and to treat cerebral edema that result from ischemia, due to interruption of blood flow, to tissue trauma or to increased tissue pressure.
