The invention relates to a stable bicarbonate ion-containing drug solution,particularly abicarbonate-containing drug solution for dialysis in which the stability hasbeen improved bythe presence of a phosphate ion. Further, the invention relates to a drugsolution for acuteblood purification, particularly a dialysate and a substitution liquid foracute blood purificationto be mixed before use containing the drug solution. Still further, theinvention relates to adialysate and a substitution liquid for acute blood purification to be mixedbefore use inwhich the formation of insoluble fine particles or precipitates is preventedfor a long timeafter mixing and with which hypokalemeia and hypophosphatemia are not caused.