ALBERTO MUNOZ GARCIA,CHRISTOPHER PETER WORRALL,ERICK GOLDMAN,MARK STEPHEN SMYTH,THIERRY BONNAUD
申请号：
BR112017020744
公开号：
BR112017020744A2
申请日:
2016.03.25
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
