The compound of present invention offer Formulas I: or its pharmaceutically acceptable salt, tautomeride or stereoisomer, wherein variable is as defined herein. The present invention also provides the pharmaceutical composition comprising this kind of compound and use the damage of this compounds for treating mammal joint or the method for joint injury and induced interstitial stem cell differentiating cartilage-forming cell.本發明提供式I的化合物:或其藥學上可接受的鹽、互變體或立體異構體,其中變量如本文所定義。本發明還提供包含這類化合物的藥物組合物和使用這類化合物治療哺乳動物關節損害或關節損傷和誘導間質幹細胞分化成軟骨細胞的方法。