A novel compound able to inhibit JAK is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.本發明揭示一種能夠抑制JAK之新穎化合物,此化合物可製備成醫藥組合物,且可用於預防及治療哺乳動物(包括人類)之多種病狀,包括(以非限制性實例之方式)發炎病狀、自體免疫疾病、增生性疾病、移植排斥、涉及軟骨轉換不良之疾病、先天性軟骨畸形及/或與IL6分泌過多有關之疾病。
