PROBLEM TO BE SOLVED: To provide a compound having TGF-bII-type receptor inhibitory activity in order to suppress scar formation.SOLUTION: A diphenylmethyl piperazine derivative represented by general formula (1) is provided. In general formula (1), X and Y each represents the case of the absence of methylene group, nitrogen atom, sulfur atom or any atom R1 is H, or alkyl or alkenyl group wherein the hydrogen atom or the carbon atom is optionally substituted with a nitrogen atom R2 is a halogen atom, amino or hydrazinyl group and R3 is a 5-18C aromatic group optionally bearing the substituent.COPYRIGHT: (C)2014,JPO&INPIT【課題】瘢痕生成を抑制すべく、TGF-bII型受容体抑制作用を有する化合物の提供。【解決手段】一般式(1)に表されるジフェニルメチルピペラジン誘導体(但し、式中X、Yはメチレン基、窒素原子、硫黄原子又は原子が存在しない場合を表し、R1は、水素原子、水素原子又は炭素原子が窒素で置換されていても良いアルキル基又はアルケニル基を表し、R2はハロゲン原子、アミノ基又はヒドラジニル基を表し、R3は前記置換基を有していても良い炭素数5~18の芳香族基を表す。)【選択図】なし
