UNIVERSITE DE LIEGE;UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
发明人:
REBOUD RAVAUX, MICHELE,YERROUM EL AMRI, CHAHRAZADE,TAN, XIAO,QIN, LIXIAN,PAGANO, MAURICE,HOVNANIAN, ALAIN,FURIO, LAETITIA,PIROTTE, BERNARD
申请号：
CA2841986
公开号：
CA2841986A1
申请日:
2012.07.13
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting ofhydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a O-R12 group, wherein R12 is a C1-C7 alkyl, a group CH2OCOR5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group O-R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a CH2-amine, R1 represents a group chosen among hydrogen and O-R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for its use for the treatment of pathologies involving an excess of activity of at least one member of the kallikrein family.
