at Ben-Gurion University;B.G. Negev Technologies and Applications Ltd.
发明人:
申请号：
EP15791991.1
公开号：
EP3142964A4
申请日:
2015.05.13
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided are co-assembled nanoparticles including at least one polypeptide including a polyanion； and at least one amphiphilic peptide capable of forming a β-sheet structure, a derivative or a salt thereof, the amphiphilic peptide including at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues in which the hydrophilic amino acid residue is positively charged, and methods of preparation of the nanoparticles. Further provided are pharmaceutical compositions including the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co-assembled nanoparticles. Further provided are therapeutic uses of the pharmaceutical compositions.
