B. G. Negev Technologies and Applications Ltd.; at Ben-Gurion University
发明人:
Hanna RAPAPORT,Ifat COHEN
申请号：
US15310286
公开号：
US20170258735A1
申请日:
2015.05.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided are co-assembled nanoparticles including at least one polypeptide including a polyanion； and at least one amphiphilic peptide capable of forming a β-sheet structure, a derivative or a salt thereof, the amphiphilic peptide including at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues in which the hydrophilic amino acid residue is positively charged, and methods of preparation of the nanoparticles. Further provided are pharmaceutical compositions including the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co-assembled nanoparticles. Further provided are therapeutic uses of the pharmaceutical compositions.
