INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,PARODY, TODD,HAN, JIE,LI, PENGYUN
申请号：
CA2904332
公开号：
CA2904332A1
申请日:
2014.03.05
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Disclosed herein are insulin agonist peptides conjugated to incretins wherein the insulin/incretin conjugate has agonist activity at both the insulin receptor and the corresponding incretin receptor. Insulin is a proven therapy for the treatment of juvenile-onset diabetes and later-stage adult-onset diabetes. The peptide is biosynthesized as a larger linear precursor of low potency (approximately 2% to 9% of native insulin), named proinsulin. Proinsulin is proteolytically converted to insulin by the selective removal of a 35-residue connecting peptide (C peptide).
