Kenneth D. James;Mark A. Miller;Navdeep B. Malkar;Nnochiri N. Ekwuribe;Monica Puskas;Michelle Ferro;Balasingam Radhakrishnan;Diti Aggarwal
发明人:
Balasingam Radhakrishnan,Diti Aggarwal,Michelle Ferro,Kenneth D. James,Navdeep B. Malkar,Mark A. Miller,Monica Puskas,Nnochiri N. Ekwuribe
申请号：
US13012146
公开号：
US09101596B2
申请日:
2011.01.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
An insulin compound coupled to a modifying moiety having a formula:—X—R1—Y-PAG-Z—R2 (Formula VI)where,X, Y and Z are independently selected linking groups and each is optionally present, and X, when present, is coupled to the insulin compound by a covalent bond,either R1 or R2 is a lower alkyl, optionally including a carbonyl group, and when R1 is a lower alkyl, R2 is a capping group, andPAG is a linear or branched carbon chain incorporating one or more alkalene glycol moieties, and optionally incorporating one or more additional moieties selected from the group consisting of —S—, —O—, —N—, and —C(O)—.
