An instrument port for introducing an instrument into a surgical site includes a port body, a bulb disposed on the distal end of the port body, and a channel extending from a proximal end to a distal end of the instrument port. The channel includes an instrument channel defined in the port body and a bulb channel defined in the bulb. An imaging system is disposed at or near the distal end of the instrument port. The imaging system is fluidically isolated from the surgical site.