A power injector (10) with help functionality is disclosed. What may be characterized as a ‘help output’ may be displayed on a graphical user interface (11) in response to a request for help. This help output may be based upon a current state of the power injector (10), may be accompanied by a cross-reference to an operator's manual for the power injector (10), may be expanded to provide additional detail, or any combination thereof. At least one system screen that relates to the help output may be displayed (e.g., simultaneously, sequentially). The help functionality may be in the form of having the power injector (10) incorporate help mode logic (256) that is configured to allow a user to view and obtain information on the various system screens that would be presented when using the power injector (10) to deliver a fluid, but without actually operating the power injector (10) to deliver fluid.