Refers to a compound of formula (i) wherein: x1, X2, X3 and X4 are n o CR7, X5, X6, X7 and x8 X9 is n or CH Z is n or CH, is pirazinilo pyridinyl, phenyl, among others R1, R2 and R3 are each h M is 1 R4 is H, halogen, difluoro - Methyl trifluoro Methyl and methyl R7 is H, halogeno, cyano, Methyl And trifluoro Methyl or phenyl e IS.Preferred compounds are: N - (6 - methoxy - benzo [d] thiazol-2-yl) - 2 - (3 - (pyridin-4-yl) - phenyl) - acetamide 2 - (3 - (2 - methoxy pyridin-4-yl) - phenyl) - N - (6 - phenyl - pyridin-3-yl) - acetamide 2 - (3 - cyano - 4 - (2 - methyl - 4 - piperidin yl) - phenyl) - N - (4 - phenyl - pyridin-3-yl) - acetamide oxide 1 - (2 - (2 - 2 , 3 - dimethyl - 5 - bipiridin 2.4 - il) acetamido) - 5 - (2 - pirazin - il) - pyridine oxide 1 - 2,3 - dimethyl - 5 - (2 - oxo - 2 - (5 - (pirazin IL - 2 - (pyridin-2-yl) amino) ethyl) - 2,4 - bipiridina among others. In addition to such a Pharmaceutical composition. This Compound is a Modulator of Wnt Signalling by inhibiting Cell Proliferation being useful in the treatment of cancerSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: X1, X2, X3 Y X4 SON N O CR7 X5, X6, X7 Y X8 SON N O CH X9 ES N O CH Z ES FENILO, PIRAZINILO, PIRIDINILO, ENTRE OTROS R1, R2 Y R3 SON CADA UNO H m ES 1 R4 ES H, HALOGENO, DIFLUORO-METILO, TRIFLUORO-METILO Y METILO R7 ES H, HALOGENO, CIANO, METILO Y TRIFLUORO-METILO E ES FENILO. SON COMPUESTOS PREFERIDOS: N-(6-METOXI-BENZO-[d]-TIAZOL-2-IL)-2-(3-(PIRIDIN-4-IL)-FENIL)-ACETAMIDA 2-(3-(2-METOXI-PIRIDIN-4-IL)-FENIL)-N-(6-FENIL-PIRIDIN-3-IL)-ACETAMIDA 2-(4-CIANO-3-(2-METIL-PIPERIDIN-4-IL)-FENIL)-N-(6-FENIL-PIRIDIN-3-IL)-ACETAMIDA 1-OXIDO DE 2-(2-(2,3-DIMETIL-2,4-BIPIRIDIN-5-IL)-ACETAMIDO)-5-(PIRAZIN-2-IL)-PIRIDINA 1-OXIDO DE 2,3-DIMETIL-5-(2-OXO-2-(5-(PIRAZIN-2-IL)-PIRIDIN-2-IL-AMINO)-ETIL)-2,4-BIPIRIDINA ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN MODULADOR DE LA SENALIZACION DE WNT INHIBIENDO LA PROLIFERACION CELULAR SIENDO UTIL EN EL TRATAMIENTO
