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Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor
专利权人:
Jong-Mook Kim;Woong Hahn
发明人:
Jong-Mook Kim,Woong Hahn
申请号:
US12908765
公开号:
US08338385B2
申请日:
2010.10.20
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
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