EASTWOOD PAUL ROBERT,GONZALEZ RODRIGUEZ JACOB,GOMEZ CASTILLO ELENA,BACH TAA JORDI
申请号：
ARP120101834
公开号：
AR086546A1
申请日:
2012.05.24
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Described are compounds that are the chemical structure represented by the formula (1)； as well as a process for their preparation, Pharmaceutical compositions containing same and their use in therapy as inhibitors of Janus Kinase (JAK).Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt or solvate or stereoisomer n-oxide or deuterated or derivative thereof, where: M is 0, 1, 2 or 3； each of X and y separately represents a nitrogen Atom or a Group - CR5,Where at least one of X and y represents a group of CR5； a and B each independently represents a nitrogen Atom or a Group - CR6, where at least one of a and B represents a Group - Cr6 Linker； W represents a group selected from a Group - a Group nr7 -, - (cr8r9) -, - or - or - S - R； 1 represents a hydrogen Atom, a linear or branched alkyl group C1 - 6A group haloalquilo c1-4, a group hidroxialquilo c1-4 alkoxy Group, a C1 - C3 - 4, a cycloalkyl Group, a group cicloalquenilo C3 - 10, an aryl Group monocyclic or bicyclic heteroaryl C6 14, a group of 5 to 14 Member contains at least a heteroatom selected from o, s and N, or a group PO Heterocyclic 5 to 14 Member contains at least a heteroatom selected from o, s and NOr a Group (CH2) - n '- C (o) - (CH2) - nr10r11 n where n' and N is 0, 1 or 2； where groups cicloalquenilo, cycloalkyl, aryl, heteroaryl and heterociclilo are unsubstituted or substituted with one or more substituents selected from a Halogen Atom, a cyano Group, an alkyl group Linear or branched C1 - 6, a group haloalquilo c1-4, a group hidroxialquilo c1-4,A Group alquilsulfonilo 4 C1 - C3 - 7, a cycloalkyl Group, a phenyl Group, a group piridilo pirimidinilo, a group or a group piperidilo； each of R2 and R6 independently represents a hydrogen Atom, an atom of halogen, a cyano Group, a linear or branched alkyl group C1 - 6 or N Group haloalquilo c1-4, a group hidroxialquilo c1-4, a cycloalkyl Group C3 - 10A cicloalquenilo C3 - 10 Group, an aryl Group monocyclic or bicyclic heteroaryl C6
