Monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)-piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, preparation, and pharmaceutical composition thereof
Yen-Fang Wen,Yuan-Jang Tsai,Wan-Ru Chen,Tsan-Lin Hu,Chia-Mu Tu,Chih-Peng Liu
申请号:
US13968089
公开号:
US09012459B2
申请日:
2013.08.15
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The disclosure is directed to a monohydrate crystalline form of 3-(5-(4-(3-fluoropropyl)piperazin-1-yl)benzimidazol-2-yl)-1-azaazulen-2-one, possessing diffraction peaks of about 12.9°, 15.9°, 17.9°, 21.2°, 22.9°, 23.5° and 24.5°. Its preparation method and pharmaceutical composition thereof are also provided.