Mito-Ob: A Transgenic Mouse Model for Obesity

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专利权人:

发明人:

Sudharsana R. Ande,Suresh Mishra

申请号：

US14328888

公开号：

US20150026833A1

申请日:

2014.07.11

申请国别(地区):

US

年份:

2015

代理人:

摘要：

An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT.

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