Josef Messinger,Heinrich-Hubert Thole,Bettina Husen,Bartholomeus Johannes Van Steen,Gyula Schneider,Johannes Bernardus Everardus Hulshof,Pasi Koskimies,Nina Johansson,Jerzy Adamski
申请号：
US10983887
公开号：
US08088758B2
申请日:
2004.11.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
3,15-substituted estrone compounds which act as inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therapeutic uses of such compounds, particularly in the treatment or inhibition of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17β-estradiol concentration, as well as the general use of selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment or inhibition of benign gynecological disorders, particularly endometriosis.
