CYTOVIA, INC.;CAI, SUI XIONG;DREWE, JOHN A.;KEMNITZER, WILLIAM E.;SIRISOMA, NILANTHA SUDATH
发明人:
CAI, SUI XIONG,DREWE, JOHN A.,KEMNITZER, WILLIAM E.,SIRISOMA, NILANTHA SUDATH
申请号：
WO2006US43080
公开号：
WO2007056208(A3)
申请日:
2006.11.02
申请国别(地区):
世界知识产权组织国际局
年份:
2007
代理人:
摘要：
Disclosed are N-arylalkyl-thienopyrimidin-4-amines and analogs thereof, represented by the Formula (I): wherein Ar, R<SUB>1</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>10</SUB>-R<SUB>12</SUB> and n are defined herein. The present invention relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
