3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

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专利权人:

CYTOVIA, INC.;CAI, SUI, XIONG;ZHANG, HAN-ZHONG;KEMNITZER, WILLIAM, E.;DREWE, JOHN, A.;SIRISOMA, NILANTHA, SUDATH

发明人:

CAI, SUI, XIONG,ZHANG, HAN-ZHONG,KEMNITZER, WILLIAM, E.,DREWE, JOHN, A.,SIRISOMA, NILANTHA, SUDATH

申请号：

WO2009US00471

公开号：

WO2009094205(A3)

申请日:

2009.01.23

申请国别(地区):

世界知识产权组织国际局

年份:

2010

代理人:

摘要：

Disclosed are 3-aryl-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and analogs thereof, represented by the Formula I wherein Ar1, Ar2, R1, R2, and X are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

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