Refers to ciclopentaoxacinilos difluoro - and difluoroenzooxacinilos Derivatives of formula (i) wherein R1, R2, R3, R4, R5, and N are as described in the present.Preferred compounds are: [3 - ((4S, 4aR, 7aR) - 2 - amino - 5.5 - difluoro - 4 - methyl - - - 4,4a 5,6,7,7a, hexahidro cyclopenta [e] [1,3] oxazin - 4-yl) phenyl] - 4 - fluoro - amide acid - 2 - 5 - but iniloxi - pyrazine carboxylic Acid - 2 - [3 - ((4S, 4aR, 7aR) - 2 - amino - 5.5 - difluoro - 4 - methyl - - - 4,4a 5,6,7,7a, hexahidro cyclopenta [e] [1,3] oxazin IL - 4 - 4 - fluoro) - phenyl] - 5 - (fluoromethyl acid amide pyrazine - 2 - carboxylic acid among others.It also relates to pharmaceutical compositions. These compounds are BACE1 Inhibitory activity to be useful in the treatment of Alzheimers diseaseSE REFIERE A DERIVADOS DE DIFLUORO-CICLOPENTAOXACINILOS Y DIFLUOROENZOOXACINILOS DE FORMULA (I) DONDE R1, R2, R3, R4, R5 Y n SON COMO SE DESCRIBEN EN EL PRESENTE. SON COMPUESTOS PREFERIDOS: [3-((4S,4aR,7aR)-2-AMINO-5,5-DIFLUORO-4-METIL-4,4a,5,6,7,7a-HEXAHIDRO-CICLOPENTA[e][1,3]OXAZIN-4-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-BUT-2-INILOXI-PIRAZINA-2-CARBOXILICO [3-((4S,4aR,7aR)-2-AMINO-5,5-DIFLUORO-4-METIL-4,4a,5,6,7,7a-HEXAHIDRO-CICLOPENTA[e][1,3]OXAZIN-4-IL)-4-FLUORO-FENIL]-AMIDA DEL ACIDO 5-FLUOROMETIL-PIRAZINA-2-CARBOXILICO ENTRE OTROS. TAMBIEN SE REFIERE A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA BACE1 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
