SOCPRA SCIENCES ET GENIE S.E.C.;SOCPRA SCIENCES ET GENIE S.E.C.
发明人:
MALOUIN, François,STER, Celine,CÔTE-GRAVEL, Julie,BROUILLETTE, Eric
申请号：
PE2019000844
公开号：
PE20191320A1
申请日:
2017.10.20
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
a. Design combination (I): xa-ligante-bz (I)；A and B are polychlorinated biphenyls saco0029 (SEQ ID No.5 and 121-131),Comment more than a month ago1. Polyurethane sacol0442 (SEQ ID No. 29 and 82-92)；Comment more than a month ago1. Polyurethane sacol0720 (SEQ ID No: 11 and 109-120)；Comment more than a month agoa polippedo sacol1416（SEQ ID No:188），1. Polyurethane sacolo611 (SEQ ID No: 189)；UN SACOL1867（SEQ ID No：152-164），Comment more than a month agoComment more than a month agoAccording to the nomenclature of Staphylococcus aureus (sacol) gene shown in NCBI NC ° u 002951.2 reference sequence, adhesive is a sequence containing at least one amino acid or nonexistent amino acid, X is nonexistent or an amino acid sequence； Z is missing or a series of amino acids The building shows a higher level of immunity and is an effective vaccine against linear oral infections caused by Staphylococcus aureus. He also mentioned a nucleic acid molecule that encodes the building, a vector,It's a living form of Staphylococcus aureus and a pharmacological component that contains the building.Referido a un constructo de fusion de formula (I): XA-ligante-BZ (I)； en donde A y B son, independientemente, un polipeptido que comprende un polipeptido SACOL0029 (SEQ ID NO: 5 y 121 a 131), un polipeptido SACOL0264 (SEQ ID NO: 185), un polipeptido SACOL0442 (SEQ ID NO: 29 y 82 a 92), un polipeptido SACOL0718 (SEQ ID NO: 186), un polipeptido SACOL0720 (SEQ ID NO: 11 y 109 a 120), un polipeptido SACOL1353 (SEQ ID NO: 187), un polipeptido SACOL1416 (SEQ ID NO: 188), un polipeptido SACOL1611 (SEQ ID NO: 189), un SACOL1867 (SEQ ID NO: 152 a 164), un polipeptido SACOL1912 (SEQ ID NO: 43), un polipeptido SACOL1944 (SEQ ID NO: 190), entre otros, sobre la base de la nomenclatura genetica del genoma COL (SACOL) de Staphylococcus aureus expuesto en la Secuencia de Referencia de NCBI NC_002951.2； el ligante es una secuencia de aminoacidos de por lo menos un aminoacido o esta ausente； X esta ausente o es una se
