The present invention is related to an antibody having treatment effect of cancer, autoimmune disease or inflammatory disease. Namely, the present invention is related to an antibody exhibiting a cytotoxic activity against cells which express receptors containing the death domain by apoptosis. The subject of the present invention is to provde a medicament having treatment effect of cancer. The solution method of the present invention is a new anti-DR5 antibody which can induce apoptosis of cell and have a remarkable cytotoxic activity comparing to the known anti-DR5 antibody.本發明係關於一種抗體,其係對於癌、自體免疫疾病或炎症性疾病具有治療效果。即,本發明係關於一種抗體,其係對於表現含有死亡區域(death domain)之受體的細胞顯示經由細胞凋亡之細胞毒殺活性。本發明之課題係提供一種醫藥品,其係對於癌具有治療效果。本發明之解決手段係一種新穎抗DR5抗體,其係可對於細胞誘導細胞凋亡,且相較於既有之抗DR5抗體具有顯著之細胞毒殺活性。
