Compounds of inhibitors of 1,3-hydroxybacterium-1 and bacterium-2； including their pharmaceutical components； preparatory procedures； for the treatment of Alzheimer's disease, type 2 diabetes mellitus, arterial thrombosis, CNCER, myocardial infarction, lupus erythematosus, E Someone else.
The present invention provides 4-(3-Amino-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.COMPUESTOS DERIVADOS DE 1,3-OXAZINAS CON ACTIVIDAD INHIBIDORA DE BACE 1 Y BACE 2； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； PROCEDIMIENTO DE PREPARACIÓN； USO EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DIABETES TIPO 2, TROMBOSIS ARTERIAL, CÁNCER, INFARTO AL MIOCARDIO,LUPUS ERITEMATOSO, ENTRE OTROS.
