Provided is an ophthalmic composition comprising the following (a), (b), or (c) geranylgeranylacetones, which protects various retinal cells from degeneration, disorder or death, and significantly enhances their survival rates. Also, the ophthalmic composition is difficult to become turbid during storage. (a) a mixture of 5E,9E,13E geranylgeranylacetone and 5Z,9E,13E geranylgeranylacetone, wherein the mixture comprises 80% or more of 5E,9E,13E geranylgeranylacetone by weight； (b) only consisting of 5E,9E,13E geranylgeranylacetone； (c) only consisting of 5Z,9E,13E geranylgeranylacetone.包含下述(a)、(b)、或(c)之香葉基香葉基丙酮之眼科用組成物，該眼科用組成物自退化、障礙、或死亡保護各種視網膜細胞，並顯著促進其存活。因此，對於各種視網膜疾病之預防、改善、或治療顯示完全功效。又，保存時難以混濁。(a)5E,9E,13E香葉基香葉基丙酮與5Z,9E,13E香葉基香葉基丙酮之混合物，此混合物包含80重量%以上之5E,9E,13E香葉基香葉基丙酮。(b)僅由5E,9E,13E香葉基香葉基丙酮組成。(c)僅由5Z,9E,13E香葉基香葉基丙酮組成。
