An ophthalmic composition containing a geranylgeranylacetone selected from (a) (b) or (c) mentioned below protects various retina cells from degeneration disorder or annihilation and significantly promotes the survival of said cells. Therefore said composition exerts a dramatic effect in the prevention amelioration or treatment of various retina disorders. Moreover the composition is less likely to become cloudy when being stored. (a) A mixture of 5E 9E 13E geranylgeranylacetone and 5Z 9E 13E geranylgeranylacetone the mixture containing 80 weight% or more of the 5E 9E 13E geranylgeranylacetone； (b) only 5E 9E 13E geranylgeranylacetone； (c) only 5Z 9E 13E geranylgeranylacetone.
