The present invention relates to a monitoring system and method for use with a body of a subject. The system comprises a medical device, having a portion thereof configured to be placed inside the subjects body, said portion of the medical device being configured to be propelled by fluid pressure through a body lumen at least two pressure sensors accommodated remotely from the subjects body at two different spaced-apart positions outside the subjects body and configured and operable to detect pressure at the two spaced-apart remote positions said at least two pressure sensors being in fluid communication with at least one site inside the subjects body, a relation between the pressure at said at least one site and the pressures at said two spaced-apart remote positions being thereby indicative of the fluid pressure at said at least one site.
