DE STAAT DER NEDERLANDEN; VERT. DOOR DE MINISTER VAN VWS; WELZIJN EN SPORT; MINISTERIE VAN VOLKSGEZONDHEID
发明人:
PETER ANDRÉ VAN DER LEY,JEROEN JOHANNES GERARDUS GEURTSEN,JOHANNES PETRUS MARIA TOMMASSEN
申请号：
PT05815467
公开号：
PT1828378E
申请日:
2005.12.16
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
