MARTIN BOHLIN,ERICA TJERNELD,ANDREAS VESTERMARK,INGVAR YMÉN
申请号：
PT14719331
公开号：
PT2989084T
申请日:
2014.04.25
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.
