Crystal modifications of elobixibat

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专利权人:

Elobix AB

发明人:

Bohlin, Martin,Tjerneld, Erica,Vestermark, Andreas,Ymen, Ingvar

申请号：

AU2014259433

公开号：

AU2014259433B2

申请日:

2014.04.25

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2- phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.

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