STIMULATION ÉPIDURALE À HAUTE DENSITÉ POUR FACILITER LA LOCOMOTION, LA POSTURE, LE MOUVEMENT VOLONTAIRE ET LE RÉTABLISSEMENT DE LA FONCTION D'AUTONOMIE, SEXUELLE, VASOMOTRICE ET COGNITIVE APRÈS LÉSION NEUROLOGIQUE
CALIFORNIA INSTITUTE OF TECHNOLOGY;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
GERASIMENKO, YURY,BURDICK, JOEL,HODES, JONATHAN,TAI, YU-CHONG,ANGELI, CLAUDIA A.,EDGERTON, VICTOR REGGIE,ROY, ROLAND R.,DESAUTELS, THOMAS ANTHONY,HARKEMA, SUSAN J.,NANDRA, MANDHEEREJ S.
申请号：
EP12732280
公开号：
EP2661307A4
申请日:
2012.01.03
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease. In certain embodiments, the methods involve stimulating the spinal cord of the subject using an epidurally placed electrode array, subjecting the subject to physical training thereby generating proprioceptive and/or supraspinal signals, and optionally administering pharmacological agents to the subject. The combination of stimulation, physical training, and optional pharmacological agents modulate in real time electrophysiological properties of spinal circuits in the subject so they are activated by supraspinal information and/or proprioceptive information derived from the region of the subject where locomotor activity is to be facilitated.
