The present invention provides derive from Raspailiidae sections, Lithoplocamia belongs to, the antitumoral compounds and its derivative of the logical formula (I) of the spongias of lithistoides kinds.本發明提供了得自Raspailiidae科、Lithoplocamia屬、lithistoides種的海綿動物的通式(I)的抗腫瘤化合物及其衍生物。